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Insects. 2012 Mar 22;3(1):324-38. doi: 10.3390/insects3010324.

Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS and Nuclear Receptor Proteins.

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Department of Biology, Fordham University, Bronx, NY 10458, USA.
Department of Biology, Fordham University, Bronx, NY 10458, USA.
Center for Cancer, Genetic Diseases, and Gene Regulation, Fordham University, Bronx, NY 10458, USA.


Juvenile hormone (JH) is responsible for controlling many biological processes. In several insect species JH has been implicated as a key regulator of developmental timing, preventing the premature onset of metamorphosis during larval growth periods. However, the molecular basis of JH action is not well-understood. In this review, we highlight recent advances which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH.


Drosophila melanogaster; bHLH-PAS; germ cell-expressed; juvenile hormone; methoprene-tolerant; nuclear receptor

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