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Insects. 2012 Mar 22;3(1):324-38. doi: 10.3390/insects3010324.

Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS and Nuclear Receptor Proteins.

Author information

1
Department of Biology, Fordham University, Bronx, NY 10458, USA. tbernardo@fordham.edu.
2
Department of Biology, Fordham University, Bronx, NY 10458, USA. dubrovsky@fordham.edu.
3
Center for Cancer, Genetic Diseases, and Gene Regulation, Fordham University, Bronx, NY 10458, USA. dubrovsky@fordham.edu.

Abstract

Juvenile hormone (JH) is responsible for controlling many biological processes. In several insect species JH has been implicated as a key regulator of developmental timing, preventing the premature onset of metamorphosis during larval growth periods. However, the molecular basis of JH action is not well-understood. In this review, we highlight recent advances which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH.

KEYWORDS:

Drosophila melanogaster; bHLH-PAS; germ cell-expressed; juvenile hormone; methoprene-tolerant; nuclear receptor

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