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BMC Psychiatry. 2015 Oct 14;15:244. doi: 10.1186/s12888-015-0636-1.

Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder.

Author information

1
Graduate School of Biomedical Sciences Programs for Biomedical Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. d095159@hiroshima-u.ac.jp.
2
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. oy@hiroshima-u.ac.jp.
3
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. koki.takagaki@gmail.com.
4
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. goookada@hiroshima-u.ac.jp.
5
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. gerutoki@hiroshima-u.ac.jp.
6
Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, Japan. tinoue@med.hokudai.ac.jp.
7
Department of Clinical Human Sciences, Graduate School of Humanities and Social Sciences, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka City, Shizuoka Prefecture, Japan. jhtanab@ipc.shizuoka.ac.jp.
8
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. koba0515@hiroshima-u.ac.jp.
9
Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan. yamawaki@hiroshima-u.ac.jp.

Abstract

BACKGROUND:

It is known that the onset, progression, and prognosis of major depressive disorder are affected by interactions between a number of factors. This study investigated how childhood abuse, personality, and stress of life events were associated with symptoms of depression in depressed people.

METHODS:

Patients with major depressive disorder (N = 113, 58 women and 55 men) completed the Beck Depression Inventory-II (BDI-II), the Neuroticism Extroversion Openness Five Factor Inventory (NEO-FFI), the Child Abuse and Trauma Scale (CATS), and the Life Experiences Survey (LES), which are self-report scales. Results were analyzed with correlation analysis and structural equation modeling (SEM), by using SPSS AMOS 21.0.

RESULTS:

Childhood abuse directly predicted the severity of depression and indirectly predicted the severity of depression through the mediation of personality. Negative life change score of the LES was affected by childhood abuse, however it did not predict the severity of depression.

CONCLUSIONS:

This study is the first to report a relationship between childhood abuse, personality, adulthood life stresses and the severity of depression in depressed patients. Childhood abuse directly and indirectly predicted the severity of depression. These results suggest the need for clinicians to be receptive to the possibility of childhood abuse in patients suffering from depression. SEM is a procedure used for hypothesis modeling and not for causal modeling. Therefore, the possibility of developing more appropriate models that include other variables cannot be excluded.

PMID:
26467656
PMCID:
PMC4604614
DOI:
10.1186/s12888-015-0636-1
[Indexed for MEDLINE]
Free PMC Article

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