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Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 2:S218-24.

[Wnt signalling pathway and cervical cancer].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. adry.aguilar.lemarroy@gmail.com.

Abstract

in English, Spanish

Cervical cancer (CC) is a pathology that arises in the cervical epithelium, whose major cause of risk is human papillomavirus (HPV) infection. Due to the fact that HPV infection per se is not enough to generate a carcinogenic process, it has been proposed that alterations in the Wnt signaling pathway are involved in cervical carcinogenesis. The Wnt family consists of 13 receptors and 19 ligands, and it is highly conserved phylogenetically due to its contribution in different biological processes, such as embryogenesis and tissue regeneration. Additionally, this signaling pathway modulates various cellular functions, for instance: cell proliferation, differentiation, migration and cell polarity. This paper describes the Wnt signaling pathways and alterations that have been found in members of this family in different cancer types and, especially, in CC.

KEYWORDS:

Cervical intraepithelial neoplasia; Papilloma; Wnt receptors

PMID:
26462520
[Indexed for MEDLINE]

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