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Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 2:S200-5.

[Apoptosis modulation by human papillomavirus].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

División de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.


in English, Spanish

One of the most important processes to keep the homeostasis in organisms is the apoptosis, also called programmed cell death. This mechanism works through two pathways: The intrinsic or mitochondrial, which responds to DNA damage and extern agents like UV radiation; and the extrinsic or receptor-mediated, which binds to their ligands to initiate the apoptotic trail. The evasion of apoptosis is one of the main causes of cellular transformation to malignity. Many viruses had shown capacity to modify the apoptotic process; among them is the human papillomavirus, which, by means of its oncoproteins, interferes in pathways, reacting with the receptors and molecules and participating in the death mechanism. This creates ideal conditions for cancer development.


Apoptosis; Human papillomavirus; Uterine cervical neoplasms

[Indexed for MEDLINE]

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