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Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 2:S140-53.

[Detection of microRNAs seed sequences within human papillomavirus genomes].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. maosal89@yahoo.com.

Abstract

in English, Spanish

In this paper we are reporting for the first time the presence of seed sequences of human and viral microRNAs embedded within both high and low risk human papillomavirus (HPV) genomes. These seed sequences have high oncogenic potential. They were found using an in silico analysis based on the microRNA sequences added to Sanger's database. Among these sequences, it was observed a potential fingerprint harbouring several repeated sequences of microRNA 297 (miR-297) within the LCR region of HPV types 16, 18, 33, 45 and 52. Further analyses were performed for low risk HPV types 6 and 11 and we observed that the probable fingerprint was absent in HPV11, even when we detected other repeated sequences of miR-363. According to these findings, besides the fact that we detected the presence of microRNA sequences within HPV genomes, we suggest a common putative viral mechanism of gene expression regulation shared among human virus.

KEYWORDS:

HPV; MicroRNAs

PMID:
26462509
[Indexed for MEDLINE]

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