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FEBS Lett. 1989 Feb 27;244(2):439-46.

Species-specific variation in signal peptide design. Implications for protein secretion in foreign hosts.

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  • 1Department of Molecular Biology, Karolinska Institute, Huddinge Hospital, Sweden.


Secretory signal peptides from individual prokaryotic and eukaryotic species have been analyzed, and the lengths and amino acid compositions of the positively charged amino-terminal region, the central hydrophobic region, and the carboxy-terminal cleavage-region have been compared. We find distinct differences between species in all three regions. Implications for protein secretion in foreign hosts are discussed.

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