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Nephrology (Carlton). 2016 Feb;21(2):81-5. doi: 10.1111/nep.12652.

Development and function of Foxp3(+) regulatory T cells.

Author information

1
Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
2
Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia.
3
Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.

Abstract

Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

KEYWORDS:

Foxp3; Tregs; autoimmunity

PMID:
26461175
DOI:
10.1111/nep.12652
[Indexed for MEDLINE]

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