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Psychoneuroendocrinology. 2016 Jan;63:198-207. doi: 10.1016/j.psyneuen.2015.09.023. Epub 2015 Sep 25.

Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner.

Author information

1
Molecular Neurobiology, Institute of Life Sciences, College of Medicine, Swansea University, UK.
2
Monash University, Victoria, Australia.
3
School of Biosciences, Cardiff University, UK.
4
Texas A&M University, College Station, TX, USA.
5
Molecular Neurobiology, Institute of Life Sciences, College of Medicine, Swansea University, UK. Electronic address: jeff.s.davies@swansea.ac.uk.

Abstract

The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the growth hormone secretagogue receptor (Ghsr), is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG). Acute elevation of acyl-ghrelin levels by injection or by overnight CR, increased DG levels of the neurogenic transcription factor, Egr-1. Two weeks of CR increased the subsequent number of mature newborn neurons in the DG of adult wild-type but not Ghsr(-/-) mice. CR wild-type mice also showed improved remote contextual fear memory. Our findings suggest that Ghsr mediates the beneficial effects of CR on enhancing adult hippocampal neurogenesis and memory.

KEYWORDS:

Adult hippocampal neurogenesis; Calorie restriction; Ghrelin; Ghsr

PMID:
26460782
PMCID:
PMC4686051
DOI:
10.1016/j.psyneuen.2015.09.023
[Indexed for MEDLINE]
Free PMC Article

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