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Oncotarget. 2015 Oct 27;6(33):34423-36. doi: 10.18632/oncotarget.5406.

Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer.

Yu Y1,2,3, Zhao Y1,2,3, Sun XH1,2,3, Ge J1,2,3, Zhang B1,2,3, Wang X1,2,3, Cao XC1,2,3.

Author information

1
The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
2
Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
3
Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

Abstract

The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and Snail transcriptionally suppressed miR-129-5p expression. Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression. Thus, miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop.

KEYWORDS:

EMT; Snail; Twist1; breast cancer progression; miR-129-5p

PMID:
26460733
PMCID:
PMC4741463
DOI:
10.18632/oncotarget.5406
[Indexed for MEDLINE]
Free PMC Article

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