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PLoS Biol. 2015 Oct 13;13(10):e1002273. doi: 10.1371/journal.pbio.1002273. eCollection 2015 Oct.

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Author information

1
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
2
Medical School, University Medical Centre, Utrecht, Netherlands.
3
Statistics and Informatics Platform, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
4
Faculty of Health, University of Tasmania, Hobart, Australia.
5
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom; Statistics and Informatics Platform, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.

Abstract

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

PMID:
26460723
PMCID:
PMC4603955
DOI:
10.1371/journal.pbio.1002273
[Indexed for MEDLINE]
Free PMC Article

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