Format

Send to

Choose Destination
Cell Mol Life Sci. 2016 Jan;73(1):147-62. doi: 10.1007/s00018-015-2061-5. Epub 2015 Oct 12.

Gut microbiota and obesity.

Author information

1
INRA, UMR1319 MICALIS, Equipe AMIPEM, Building 442, Domaine de Vilvert, 78350, Jouy-en-Josas, France. philippe.gerard@jouy.inra.fr.
2
AgroParisTech, UMR MICALIS, 78350, Jouy-en-Josas, France. philippe.gerard@jouy.inra.fr.

Abstract

The human intestine harbors a complex bacterial community called the gut microbiota. This microbiota is specific to each individual despite the existence of several bacterial species shared by the majority of adults. The influence of the gut microbiota in human health and disease has been revealed in the recent years. Particularly, the use of germ-free animals and microbiota transplant showed that the gut microbiota may play a causal role in the development of obesity and associated metabolic disorders, and lead to identification of several mechanisms. In humans, differences in microbiota composition, functional genes and metabolic activities are observed between obese and lean individuals suggesting a contribution of the gut microbiota to these phenotypes. Finally, the evidence linking gut bacteria to host metabolism could allow the development of new therapeutic strategies based on gut microbiota modulation to treat or prevent obesity.

KEYWORDS:

Antibiotics; Fecal transplant; Gnotobiotic models; Intestinal permeability; Metabolic syndrome; Microbiome; Prebiotics; Probiotics

PMID:
26459447
DOI:
10.1007/s00018-015-2061-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center