Format

Send to

Choose Destination
Curr Genet. 2016 Feb;62(1):125-8. doi: 10.1007/s00294-015-0524-8. Epub 2015 Oct 12.

Bacterial differentiation via gradual activation of global regulators.

Author information

1
Terrestrial Biofilms Group, Institute of Microbiology, Friedrich Schiller University Jena, 07743, Jena, Germany. akos-tibor.kovacs@uni-jena.de.

Abstract

Bacteria have evolved to adapt to various conditions and respond to certain stress conditions. The ability to sense and efficiently reply to these environmental effects involve versatile array of sensors and global or specific regulators. Interestingly, modulation of the levels of active global regulators enables bacteria to respond to diverse signals via a single central transcriptional regulator and to activate or repress certain differentiation pathways at a spatio-temporal manner. The Gram-positive Bacillus subtilis is an ideal bacterium to study how membrane bound and cytoplasmic sensor kinases affect the level of phosphorylated global regulator, Spo0A which in response activates genes related to sliding, biofilm formation, and sporulation. In addition, other global regulators, including the two-component system DegS-DegU, modulate overlapping and complementary genes in B. subtilis related to surface colonization and biofilm formation. The intertwinement of global regulatory systems also allows the accurate modulation of differentiation pathways. Studies in the last decade enable us to get a deeper insight into the role of global regulators on the smooth transition of developmental processes in B. subtilis.

KEYWORDS:

Bacillus subtilis; Biofilm formation; Global regulator; Sensor kinase; Sliding; Sporulation

PMID:
26458398
DOI:
10.1007/s00294-015-0524-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center