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J Neuroimaging. 2016 May;26(3):351-4. doi: 10.1111/jon.12308. Epub 2015 Oct 13.

Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction.

Author information

1
Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
2
Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.
3
Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC.
4
Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
5
Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Ilsan, Korea.
6
Department of Neurology, CHA University College of Medicine, Bundang, Korea.
7
Department of Neurology, National Medical Center, Seoul, Korea.
8
Department of Neurology, Sanbon Hospital, Wonkwang University College of Medicine, Sanbon, Korea.
9
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND AND PURPOSE:

The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction.

METHODS:

The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software.

RESULTS:

Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm(3) (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003).

CONCLUSIONS:

This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.

KEYWORDS:

Lacunar infarcts; uric acid; white matter hyperintensities

PMID:
26458336
DOI:
10.1111/jon.12308
[Indexed for MEDLINE]

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