Send to

Choose Destination
See comment in PubMed Commons below
Am J Med. 1989 Mar;86(3):315-8.

Pseudohyponatremia: a reappraisal.

Author information

  • 1Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden.


Pseudohyponatremia is a falsely low serum sodium measurement. It occurs in cases of extreme hyperlipidemia or hyperproteinemia when serum sodium is measured by some--but not all--laboratory methods. This article reviews the most common techniques for measuring serum sodium levels, explains why pseudohyponatremia occurs, and identifies specific situations in which pseudohyponatremia can lead to dangerous errors in patient management. The review describes the dramatic change in prevalence of the different laboratory methods for measuring serum sodium over the past decade, and emphasizes the need for clinicians to be familiar with the methods of their clinical laboratory in order to properly interpret a reported serum sodium determination. I offer recommendations for the rational use of the different laboratory methods in various clinical situations.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center