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Bioimpacts. 2015;5(3):123-7. doi: 10.15171/bi.2015.20. Epub 2015 Jul 26.

Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders.

Author information

1
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress n eeds to be re-evaluated by experts.

KEYWORDS:

Biomarker; Oxidative stress; Thiobarbitoric acid reactive substances

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