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Part Part Syst Charact. 2015 Aug;32(8):809-816. Epub 2015 May 12.

A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering.

Author information

1
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).
2
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA). Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210 (USA).
3
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 (USA).
4
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA). Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 (USA).

Abstract

This article describes a biomimetic core-shell platform with a collagen-based core and an alginate hydrogel shell for cell and tissue culture. With this system, chemical and physical properties of extracellular matrix (ECM) in the core microenvironment can be controlled to regulate proliferation and development of cells/tissues under miniaturized three-dimensional (3D) culture.

KEYWORDS:

3D culture; biomimetic; core-shell microcapsule; follicle; stem cell

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