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Clin Breast Cancer. 2016 Aug;16(4):262-8. doi: 10.1016/j.clbc.2015.09.012. Epub 2015 Sep 25.

Hypofractionated Breast Radiation: Shorter Scheme, Lower Toxicity.

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Department of Radiotherapy and Oncology, Virgen de las Nieves University Hospital, Granada, Spain. Electronic address:
Department of Radiotherapy and Oncology, Virgen de las Nieves University Hospital, Granada, Spain.
Institute of Biosanitaria ibs, Virgen de las Nieves University Hospital, Granada, Spain.



We analyzed the toxicity and cosmetic outcomes for patients who had undergone 3-dimensional conformal radiotherapy with a hypofractionated schedule and identified the risk factors associated with such a schedule.


A total of 143 patients were treated for breast cancer (stage 0-III) with a hypofractionated radiation schedule after breast-conserving surgery from 2006 to 2011. Most patients received 42.4 Gy in 16 daily fractions, 2.65 Gy per fraction to the whole breast plus an additional simultaneous integrated or sequential boost to the tumor bed.


The median follow-up period was 36 months. Mild acute skin toxicity was observed in 62%; 7% of the patients developed moderate skin toxicity, but no grade 4 toxicity was observed. The prevalence of fibrosis within the boost area was 5%, but no grade ≥ 2 was observed. The prevalence of fibrosis of any grade was greater in the nonboost (23%) than in the boost area. Of all the patients, 91% had good or excellent cosmetic outcomes. From the multivariate analysis, the incidence of epithelitis correlated with the patient's treated volume (P = .044). The incidence of acute toxicity correlated with the boost type to the tumor bed and the total treatment dose (P = .012 and P = .002, respectively). Also, a poor to fair cosmetic outcome was significantly associated statistically with the surgery type (P = .05), boost type (P = .004), and total dose (P = .001).


Delivering whole-breast irradiation with a hypofractionated schedule of 42.4 Gy plus a simultaneous integrated boost to the tumor bed appears to be a safe and effective technique, with good cosmetic results and lower toxicity.


Breast cancer; Cosmesis; Radiotherapy; Regional nodal irradiation; Simultaneous integrated boost

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