Format

Send to

Choose Destination
J Oral Maxillofac Surg. 2016 Mar;74(3):523-7. doi: 10.1016/j.joms.2015.09.015. Epub 2015 Sep 25.

Tumor Infiltration Depth as Predictor of Nodal Metastasis in Early Tongue Squamous Cell Carcinoma.

Author information

1
Researcher, Department of Biomedical and Neuromotor Sciences, University of Bologna; Section of Maxillofacial Surgery, Policlinico S Orsola-Malpighi, Bologna, Italy.
2
PhD student, Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, Italy. Electronic address: giacomo.delcorso@unibo.it.
3
Medical Doctor, Pathology Unit, Policlinico S Orsola-Malpighi, Bologna, Italy.
4
Professor of Oral and Maxillofacial Surgery, Department of Biomedical and Neuromotor Sciences, University of Bologna; Section of Maxillofacial Surgery, Policlinico S Orsola-Malpighi, Bologna, Italy.

Abstract

PURPOSE:

A retrospective longitudinal study was conducted to identify the cutoff value of infiltration depth for predicting the risk of lymph node metastasis of the neck in a well-defined population of surgically treated patients affected by stage T1 to T2 oral squamous cell carcinoma of the tongue.

PATIENTS AND METHODS:

Sixty-seven patients were enrolled in this study. Forty-four patients (65.5%) had pN0 status and 23 (34.5%) had pN(+) status. Thirty-five positive lymph nodes were analyzed. The median follow-up for these patients was 51.4 months.

RESULTS:

The mean infiltration depth of the N-negative group was 2.4 mm; this was substantially different from the mean value observed in the N-positive group at 5.5 mm. A meaningful cutoff was identified at an infiltration depth value of 4 mm.

CONCLUSION:

Infiltration depth was identified as an important predictor for neck nodal status. In this specific population, mortality was associated with increasing tumor infiltration depth.

PMID:
26454032
DOI:
10.1016/j.joms.2015.09.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center