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Bone. 2015 Nov;80:131-142. doi: 10.1016/j.bone.2015.03.015.

Inflammation induced loss of skeletal muscle.

Author information

1
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
2
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: denis.guttridge@osumc.edu.

Abstract

Inflammation is an important contributor to the pathology of diseases implicated in skeletal muscle dysfunction. A number of diseases and disorders including inflammatory myopathies and Chronic Obstructive Pulmonary Disorder (COPD) are characterized by chronic inflammation or elevation of the inflammatory mediators. While these disease states exhibit different pathologies, all have in common the loss of skeletal muscle mass and a deregulated skeletal muscle physiology. Pro-inflammatory cytokines are key contributors to chronic inflammation found in many of these diseases. This section of the review focuses on some of the known inflammatory disorders like COPD, Rheumatoid Arthritis (RA) and inflammatory myopathies that display skeletal muscle atrophy and also provides the reader an overview of the mediators of inflammation, their signaling pathways, and mechanisms of action. This article is part of a Special Issue entitled "Muscle Bone Interactions".

KEYWORDS:

Atrophy; Cytokines; Differentiation; Inflammation; Muscle; Skeletal

PMID:
26453502
PMCID:
PMC4600538
DOI:
10.1016/j.bone.2015.03.015
[Indexed for MEDLINE]
Free PMC Article

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