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Bone. 2015 Nov;80:115-125. doi: 10.1016/j.bone.2015.02.008.

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.

Author information

1
Biozentrum, Div. of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland.
2
Biozentrum, Div. of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland. Electronic address: christoph.handschin@unibas.ch.

Abstract

An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has been linked to an elevated risk for many chronic diseases. The discovery of myokines, hormones produced by skeletal muscle tissue, suggests the possibility that these might be molecular mediators of the whole body effects of exercise originating from contracting muscle fibers. Even though less is known about the sedentary state, the lack of contraction-induced myokines or the production of a distinct set of hormones in the inactive muscle could likewise contribute to pathological consequences in this context. In this review, we try to summarize the most recent developments in the study of muscle as an endocrine organ and speculate about the potential impact on our understanding of exercise and sedentary physiology, respectively. This article is part of a Special Issue entitled "Muscle Bone Interactions".

KEYWORDS:

Exercise; Inflammation; Myokines; PGC-1α; Skeletal muscle

PMID:
26453501
PMCID:
PMC4657151
DOI:
10.1016/j.bone.2015.02.008
[Indexed for MEDLINE]
Free PMC Article

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