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Trends Genet. 2015 Nov;31(11):613-626. doi: 10.1016/j.tig.2015.09.002. Epub 2015 Oct 8.

miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants.

Author information

1
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
2
European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.
3
Utah Science, Technology, and Research Center for Genetic Discovery, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA.
4
Mouse Genome Informatics, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
5
ZFIN, 5291 University of Oregon, Eugene, OR 97403-5291, USA.
6
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. Electronic address: jpostle@uoneuro.uoregon.edu.

Abstract

High-throughput sequencing of miRNAs has revealed the diversity and variability of mature and functional short noncoding RNAs, including their genomic origins, biogenesis pathways, sequence variability, and newly identified products such as miRNA-offset RNAs (moRs). Here we review known cases of alternative mature miRNA-like RNA fragments and propose a revised definition of miRNAs to encompass this diversity. We then review nomenclature guidelines for miRNAs and propose to extend nomenclature conventions to align with those for protein-coding genes established by international consortia. Finally, we suggest a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of small RNA sequencing experiments.

KEYWORDS:

isomiR; loop-origin miRNAs; miRNA cluster; miRNA-seq; moR; noncoding RNA

PMID:
26453491
PMCID:
PMC4639415
DOI:
10.1016/j.tig.2015.09.002
[Indexed for MEDLINE]
Free PMC Article

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