Format

Send to

Choose Destination
J Biol Chem. 2015 Nov 27;290(48):28613-22. doi: 10.1074/jbc.R115.655118. Epub 2015 Oct 9.

Actin Out: Regulation of the Synaptic Cytoskeleton.

Author information

1
From the Departments of Cell Biology and.
2
From the Departments of Cell Biology and Neurobiology, Duke University, School of Medicine, Durham, North Carolina 27710 scott.soderling@duke.edu.

Abstract

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during spinogenesis and experience-dependent plasticity. Multiple mutations associated with human neurodevelopmental and psychiatric disorders involve genes that encode regulators of the synaptic cytoskeleton. A major, unresolved question is how the disruption of specific actin filament structures leads to the onset and progression of complex synaptic and behavioral phenotypes. This review will cover established and emerging mechanisms of actin cytoskeletal remodeling and how this influences specific aspects of spine biology that are implicated in disease.

KEYWORDS:

Arp2/3 complex; Rho (Rho GTPase); WASH; actin; adhesion; cofilin; dendritic spine; formin; synapse; synaptic plasticity

PMID:
26453304
PMCID:
PMC4661376
DOI:
10.1074/jbc.R115.655118
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center