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Oncotarget. 2015 Nov 3;6(34):35699-709. doi: 10.18632/oncotarget.5372.

The tissue dependent interactions between p53 and Bcl-2 in vivo.

Author information

1
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 200437.
2
Shanghai University of Traditional Chinese Medicine, Shanghai, China, 201203.
3
Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA.

Abstract

To further investigate the role of p53 in apoptosis in vivo and the interaction between p53 and Bcl-2 in the regulation of cellular apoptosis in vivo, we depleted p53 in Bcl-2-null mice. We found that the interaction between p53 and Bcl-2 are tissue dependent. Specifically, loss of p53 in Bcl-2-/- mice inhibits apoptotic induction in spleen and subsequently inhibits the Bcl-2-null-induced spleen atrophy. Furthermore, p53 deficiency overcomes loss of melanocyte stem cell (MSC)-induced apoptosis and subsequently prevents hair graying in Bcl-2- null mice. In addition, p53 deletion partly inhibits apoptosis in hair follicle keratinocytes, leading to the alleviation of hair growth delay in Bcl-2-null mice. However, p53 absence in Bcl-2-null mice cannot restore other defects in Bcl-2-null mice, including retardation of growth, short ears and polycystic kidney disease.

KEYWORDS:

Bcl-2; apoptosis; interaction; mice; p53

PMID:
26452131
PMCID:
PMC4742135
DOI:
10.18632/oncotarget.5372
[Indexed for MEDLINE]
Free PMC Article

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