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Cell. 2015 Oct 8;163(2):340-53. doi: 10.1016/j.cell.2015.09.020.

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila.

Author information

1
The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK.
2
Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton SO16 6YD, UK.
3
National Resource for Imaging Mass Spectroscopy, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA.
4
The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK. Electronic address: alex.gould@crick.ac.uk.

Abstract

Stem cells reside in specialized microenvironments known as niches. During Drosophila development, glial cells provide a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation. We now find that the glial cell niche also preserves neuroblast proliferation under conditions of hypoxia and oxidative stress. Lipid droplets that form in niche glia during oxidative stress limit the levels of reactive oxygen species (ROS) and inhibit the oxidation of polyunsaturated fatty acids (PUFAs). These droplets protect glia and also neuroblasts from peroxidation chain reactions that can damage many types of macromolecules. The underlying antioxidant mechanism involves diverting PUFAs, including diet-derived linoleic acid, away from membranes to the core of lipid droplets, where they are less vulnerable to peroxidation. This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.

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PMID:
26451484
PMCID:
PMC4601084
DOI:
10.1016/j.cell.2015.09.020
[Indexed for MEDLINE]
Free PMC Article

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