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Int J Chron Obstruct Pulmon Dis. 2015 Sep 24;10:2017-25. doi: 10.2147/COPD.S91654. eCollection 2015.

Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients.

Author information

1
Department of Pulmonology, Semmelweis University, Budapest, Hungary.
2
Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
3
Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.

Abstract

INTRODUCTION:

The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown.

AIM:

Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters.

METHODS:

A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients.

RESULTS:

The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86±1.79 ng/mL and 14.27±1.88 ng/mL vs 25.66±1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group.

CONCLUSION:

Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.

KEYWORDS:

ACOS; CAT; obstructive lung disease

PMID:
26451099
PMCID:
PMC4590340
DOI:
10.2147/COPD.S91654
[Indexed for MEDLINE]
Free PMC Article

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