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FEBS Lett. 2015 Nov 14;589(22):3438-48. doi: 10.1016/j.febslet.2015.09.022. Epub 2015 Oct 6.

Emerging targets for combination therapy in melanomas.

Author information

1
Center for Translational Research in Oncology (LIM24), Dept. of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, Brazil.
2
Center for Translational Research in Oncology (LIM24), Dept. of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, Brazil. Electronic address: rchammas@usp.br.

Abstract

Cutaneous melanomas are often difficult to treat when diagnosed in advanced stages. Melanoma cells adapt to survive in extreme environmental conditions and are among the tumors with larger genomic instability. Here we discuss some intrinsic and extrinsic mechanisms of resistance of melanoma cells to both conventional and target therapies, such as autophagy, adaptation to endoplasmic reticulum stress, metabolic reprogramming, mechanisms of tumor repopulation and the role of extracellular vesicles in this later phenomenon. These biological processes are potentially targetable and thus provide a platform for research and discovery of new drugs for combination therapy to manage melanoma patient treatment.

KEYWORDS:

Autophagy; Melanoma; Metabolic reprogramming; PAF; Tumor repopulation; Unfolded protein response

PMID:
26450371
DOI:
10.1016/j.febslet.2015.09.022
[Indexed for MEDLINE]
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