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Genome Biol. 2015 Oct 8;16:222. doi: 10.1186/s13059-015-0781-3.

Do count-based differential expression methods perform poorly when genes are expressed in only one condition?

Author information

1
SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, CH-8057, Switzerland. xiaobei.zhou@uzh.ch.
2
Institute of Molecular Life Sciences, University of Zurich, Zurich, CH-8057, Switzerland. xiaobei.zhou@uzh.ch.
3
SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, CH-8057, Switzerland. mark.robinson@imls.uzh.ch.
4
Institute of Molecular Life Sciences, University of Zurich, Zurich, CH-8057, Switzerland. mark.robinson@imls.uzh.ch.

Abstract

A response to 'Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data' by Rapaport F, Khanin R, Liang Y, Pirun M, Krek A, Zumbo P, Mason CE, Socci ND and Betel D in Genome Biology, 2013, 14:R95.

Comment in

PMID:
26450178
PMCID:
PMC4599205
DOI:
10.1186/s13059-015-0781-3
[Indexed for MEDLINE]
Free PMC Article

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