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Pathog Dis. 2015 Dec;73(9):ftv089. doi: 10.1093/femspd/ftv089. Epub 2015 Oct 7.

Non-haemolytic and non-pigmented group b streptococcus, an infrequent cause of early onset neonatal sepsis.

Author information

1
University Hospital Virgen de las Nieves, Microbiology, Granada, 18014 Spain.
2
University Hospital of Ulm, Institute of Medical Microbiology and Hospital Hygiene, Ulm, 89081 Germany.
3
University Hospital Virgen de las Nieves, Microbiology, Granada, 18014 Spain mdelarosa@outlook.es.

Abstract

The haemolysin of Group B streptococci (GBS), a leading cause of neonatal infections, is a key virulence factor that has been implicated in the development of invasive infection. The frequency of non-haemolytic (NH) GBS isolates is around 5% among GBS carriers. To determine if similar rates are observed among invasive strains, we evaluated the incidence of NH strains among 199 GBS strains isolated from neonatal blood cultures (first week of life). Overall, we found two (1%) NH strains. This finding suggests that the frequency of NH GBS strains causing early onset invasive neonatal infection is lower than the reported frequency of NH GBS among colonizing strains.

KEYWORDS:

GBS; GBS haemolysin; Streptococcus agalactiae; neonatal sepsis

PMID:
26449711
PMCID:
PMC4626576
DOI:
10.1093/femspd/ftv089
[Indexed for MEDLINE]
Free PMC Article

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