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Am J Respir Cell Mol Biol. 2016 Mar;54(3):299-305. doi: 10.1165/rcmb.2015-0218TR.

Sleep Apnea Research in Animals. Past, Present, and Future.

Author information

1
Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of the upper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

KEYWORDS:

animal; fragmentation; intermittent hypoxia; sleep apnea

PMID:
26448201
PMCID:
PMC4821036
[Available on 2017-03-01]
DOI:
10.1165/rcmb.2015-0218TR
[Indexed for MEDLINE]
Free PMC Article

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