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Clin Exp Metastasis. 2016 Jan;33(1):97-113. doi: 10.1007/s10585-015-9755-9. Epub 2015 Oct 7.

Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors.

Author information

1
London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada.
2
Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
3
London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada. alison.allan@lhsc.on.ca.
4
Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. alison.allan@lhsc.on.ca.
5
Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. alison.allan@lhsc.on.ca.
6
Lawson Health Research Institute, London, ON, Canada. alison.allan@lhsc.on.ca.
7
London Regional Cancer Program, Room A4-132, 790 Commissioners Road East, London, ON, N6A 4L6, Canada. alison.allan@lhsc.on.ca.

Abstract

There is accumulating evidence indicating that aldehyde dehydrogenase (ALDH) activity selects for cancer cells with increased aggressiveness, capacity for sustained proliferation, and plasticity in primary tumors. However, emerging data also suggests an important mechanistic role for the ALDH family of isoenzymes in the metastatic activity of tumor cells. Recent studies indicate that ALDH correlates with either increased or decreased metastatic capacity in a cellular context-dependent manner. Importantly, it appears that different ALDH isoforms support increased metastatic capacity in different tumor types. This review assesses the potential of ALDH as biological marker and mechanistic mediator of metastasis in solid tumors. In many malignancies, most notably in breast cancer, ALDH activity and expression appears to be a promising marker and potential therapeutic target for treating metastasis in the clinical setting.

KEYWORDS:

Aldehyde dehydrogenase; Biomarker; Cancer stem cell; Metastasis; Solid tumors

PMID:
26445849
PMCID:
PMC4740561
DOI:
10.1007/s10585-015-9755-9
[Indexed for MEDLINE]
Free PMC Article

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