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Cell Metab. 2015 Oct 6;22(4):540-1. doi: 10.1016/j.cmet.2015.09.021.

Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity.

Author information

1
Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
2
Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.

Abstract

Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.

PMID:
26445509
DOI:
10.1016/j.cmet.2015.09.021
[Indexed for MEDLINE]
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