Format

Send to

Choose Destination
J Alzheimers Dis. 2016;49(1):179-85. doi: 10.3233/JAD-150388.

Risk of dementia in patients with celiac disease: a population-based cohort study.

Author information

1
Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
2
Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.
3
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
4
Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
5
Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.

Abstract

BACKGROUND:

Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD.

OBJECTIVE:

To determine whether patients with CD have an increased risk of dementia.

METHODS:

Using a population-based database of older adults (age ≥50 years) with histologically proven CD (duodenal/jejunal villous atrophy) from all 28 pathology departments in Sweden, we compared the incidence of a subsequent dementia diagnosis to those of age- and gender-matched controls.

RESULTS:

Among patients with CD (n = 8,846) and controls (n = 43,474), the median age was 63 years and 56% were female. During a median follow-up time of 8.4 years, dementia was diagnosed in 4.3% of CD patients and 4.4% of controls (HR 1.07; 95% CI 0.95-1.20). Although there was an increased risk of dementia in the first year following a diagnosis of CD (HR 1.73; 95% CI 1.15-2.61), this risk was not present in the whole observation period. Among those subjects with a dementia subtype specified, the increased risk was restricted to vascular dementia (HR 1.28; 95% CI 1.00-1.64) and was not present for Alzheimer's dementia (HR 1.12; 95% CI 0.91-1.37).

CONCLUSIONS:

Patients with CD are not at increased risk for dementia overall, though subgroup analysis suggests that they may be at increased risk for vascular dementia.

KEYWORDS:

Alzheimer’s disease; celiac disease; dementia; epidemiology

PMID:
26444775
DOI:
10.3233/JAD-150388
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IOS Press
Loading ...
Support Center