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J Alzheimers Dis. 2015;48(4):937-48. doi: 10.3233/JAD-150253.

Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?

Author information

1
Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
2
icoMetrix, Leuven, Belgium.
3
Department of Radiology, Antwerp University Hospital & University of Antwerp, Antwerp, Belgium.
4
iMinds-Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium.
5
Center for Biomedical Imaging, New York University Langone Medical Center, New York, NY, USA.
6
Department of Experimental Psychology, University of Ghent, Ghent, Belgium.
7
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.
8
Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
9
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.

Abstract

The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimer's disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age- and gender-matched patients with mild cognitive impairment (MCI) due to AD (n = 18), dementia due to AD (n = 19), and age-matched cognitively healthy controls (n = 14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.

KEYWORDS:

Alzheimer’s disease; biomarker; diffusion kurtosis imaging; diffusion tensor imaging; early diagnosis; magnetic resonance imaging; mild cognitive impairment

PMID:
26444762
PMCID:
PMC4927852
DOI:
10.3233/JAD-150253
[Indexed for MEDLINE]
Free PMC Article

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