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PLoS One. 2015 Oct 7;10(10):e0139978. doi: 10.1371/journal.pone.0139978. eCollection 2015.

Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice.

Author information

1
Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
2
Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Metastasis to the liver is a main factor in colorectal cancer mortality. Previous studies suggest that chronic psychological stress is important in cancer progression, but its effect on liver metastasis has not been investigated. To address this, we established a liver metastasis model in BALB/c nude mice to investigate the role of chronic stress in liver metastasis. Our data suggest that chronic stress elevates catecholamine levels and promotes liver metastasis. Chronic stress was also associated with increased tumor associated macrophages infiltration into the primary tumor and increased the expression of metastatic genes. Interestingly, β-blocker treatment reversed the effects of chronic stress on liver metastasis. Our results suggest the β-adrenergic signaling pathway is involved in regulating colorectal cancer progression and liver metastasis. Additionally, we submit that adjunctive therapy with a β-blocker may complement existing colorectal cancer therapies.

PMID:
26444281
PMCID:
PMC4596521
DOI:
10.1371/journal.pone.0139978
[Indexed for MEDLINE]
Free PMC Article

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