Format

Send to

Choose Destination
J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):850-7. doi: 10.1093/gerona/glv170. Epub 2015 Oct 5.

Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

Author information

1
Department of Medicine.
2
Department of Pathology, and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio. Research Service and Geriatric Research and Education Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio.
3
Department of Pathology, and.
4
The Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio.
5
Department of Medicine, Research Service and Geriatric Research and Education Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio.
6
Department of Pathology, and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio.
7
ROCA/Department of Geriatric Medicine, University of Oklahoma Health Science Center and the Oklahoma City VA Medical Center. Arlan-richardson@ouhsc.edu.
8
Department of Medicine, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio. Research Service and.

Abstract

We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr (db/db) mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

KEYWORDS:

Life span; Obesity; Toxicity; mTOR Inhibition

PMID:
26442901
PMCID:
PMC4906320
DOI:
10.1093/gerona/glv170
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center