Format

Send to

Choose Destination
Annu Rev Genet. 2015;49:603-25. doi: 10.1146/annurev-genet-112414-054813. Epub 2015 Oct 5.

General Stress Signaling in the Alphaproteobacteria.

Author information

1
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637; email: scrosson@uchicago.edu.

Abstract

The Alphaproteobacteria uniquely integrate features of two-component signal transduction and alternative σ factor regulation to control transcription of genes that ensure growth and survival across a range of stress conditions. Research over the past decade has led to the discovery of the key molecular players of this general stress response (GSR) system, including the sigma factor σ(EcfG), its anti-σ factor NepR, and the anti-anti-σ factor PhyR. The central molecular event of GSR activation entails aspartyl phosphorylation of PhyR, which promotes its binding to NepR and thereby releases σ(EcfG) to associate with RNAP and direct transcription. Recent studies are providing a new understanding of complex, multilayered sensory networks that activate and repress this central protein partner switch. This review synthesizes our structural and functional understanding of the core GSR regulatory proteins and highlights emerging data that are defining the systems that regulate GSR transcription in a variety of species.

KEYWORDS:

ECF sigma factor; HWE and HisKA_2 kinases; PhyR; partner switch; signal transduction; two-component signaling

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center