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Chem Commun (Camb). 2015 Dec 11;51(95):16960-3. doi: 10.1039/c5cc04784f.

Label-free detection of pH based on the i-motif using an aggregation-caused quenching strategy.

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College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Institute of Advanced Studies - 68756663, China.


A label-free and biocompatible pH sensor system based on the aggregation-caused quenching (ACQ) probe has been reported herein. The DNA i-motif, a kind of pH-triggered structure, affects the aggregation of PTCDI derivatives by structural switch that would provide significant fluorescence signals responding to the different pH values. Our method not only shows sensitive and reversible response to pH changes, but also could expand the detection range by allosteric control of the DNA i-motif.


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