[Early diagnosis of prostate cancer by combined use of Trp-p8 expression and PSA density of the transition zone]

Zhonghua Nan Ke Xue. 2015 Aug;21(8):724-8.
[Article in Chinese]

Abstract

Objective: To study the expression of the Trp-p8 protein in the prostate tissue of the PSA "grey zone" with different PSA density of the transition zone (PSADTZ) and explore the value of determining Trp-p8 expression and PSADTZ in the early diagnosis of prostate cancer (PCa).

Methods: This study involved 30 cases of benign prostatic hyperplasia (BPH) and another 30 cases of PCa with different PSADTZ values. Using a data imaging and analysis system, we determined the expression levels of Trp-p8 in BPH and PCa tissues and analyzed their correlation with PSADTZ.

Results: The expression of Trp-p8 was weak or negative in the BPH but strong in the PCa tissue and even stronger in the PCa tissue with high PSADTZ (F = 34. 05, P < 0.05).

Conclusion: The Trp-p8 protein is expressed differently in BPH and PCa tissues of the PSA " grey zone" and its expression is positively correlated with PSADTZ. Determination of the Trp-p8 expression and PSADTZ contributes to the early diagnosis of prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / metabolism*
  • Early Detection of Cancer / methods*
  • Humans
  • Male
  • Prostate / metabolism*
  • Prostate-Specific Antigen / metabolism*
  • Prostatic Hyperplasia / diagnosis*
  • Prostatic Hyperplasia / metabolism
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / metabolism
  • TRPM Cation Channels / metabolism*

Substances

  • Biomarkers, Tumor
  • TRPM Cation Channels
  • TRPM8 protein, human
  • Prostate-Specific Antigen