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J Clin Epidemiol. 2016 Feb;70:214-23. doi: 10.1016/j.jclinepi.2015.09.016. Epub 2015 Oct 9.

Million Veteran Program: A mega-biobank to study genetic influences on health and disease.

Author information

1
Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), VA Cooperative Studies Program, VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA; Department of Internal Medicine, Harvard Medical School, Boston, MA, USA.
2
Clinical Epidemiology Research Center (CERC), VA Cooperative Studies Program, VA Connecticut Healthcare System, 950 Campbell Avenue, 151B, West Haven, CT 06516, USA; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: john.concato@va.gov.
3
Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), VA Cooperative Studies Program, VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA; Department of Internal Medicine, Boston University School of Medicine, Boston, MA, USA.
4
Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), VA Cooperative Studies Program, VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA.
5
Clinical Epidemiology Research Center (CERC), VA Cooperative Studies Program, VA Connecticut Healthcare System, 950 Campbell Avenue, 151B, West Haven, CT 06516, USA; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
6
Clinical Epidemiology Research Center (CERC), VA Cooperative Studies Program, VA Connecticut Healthcare System, 950 Campbell Avenue, 151B, West Haven, CT 06516, USA.
7
Office of Research and Development, Veterans Health Administration, 810 Vermont Avenue N.W., 10P9, Washington, DC 20420, USA.

Abstract

OBJECTIVE:

To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system.

STUDY DESIGN AND SETTING:

Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses.

RESULTS:

Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of August 3, 2015, and with a steady state of ≈50 recruiting sites nationwide, N = 397,104 veterans have been enrolled. Among N = 199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). On the basis of self-reported race, white (77.2%) and African American (13.5%) populations are well represented.

CONCLUSIONS:

By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.

KEYWORDS:

Cohort studies; Exome sequencing; Genomics; Genotyping; Veterans; Whole-genome sequencing

PMID:
26441289
DOI:
10.1016/j.jclinepi.2015.09.016
[Indexed for MEDLINE]
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