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Trends Immunol. 2015 Nov;36(11):665-667. doi: 10.1016/j.it.2015.09.003. Epub 2015 Oct 1.

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance.

Author information

1
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: schietia@mskcc.org.

Abstract

Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations. In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for 'non-genomic' drivers in cancer evolution.

PMID:
26440701
PMCID:
PMC5104493
DOI:
10.1016/j.it.2015.09.003
[Indexed for MEDLINE]
Free PMC Article

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