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Gynecol Endocrinol. 2015;31(11):833-9. doi: 10.3109/09513590.2015.1041906. Epub 2015 Oct 6.

Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis.

Author information

1
a School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , The People's Republic of China.

Abstract

OBJECTIVE:

To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS).

STUDY DESIGN:

MEDLINE and ScienceDirect were searched to retrieve relevant trials. The endpoint was the incidence of complications of pregnancy, gestational diabetes mellitus (GDM), pre-eclampsia (PE), miscarriage and premature birth included.

RESULTS:

Five studies with 502 PCOS patients with metformin administration throughout pregnancy and 427 controls who used metformin just to get conception were included in our meta-analysis. In study group, a significantly lower change of emerging miscarriage and premature birth was observed, the pooled relative risk (RR) was 0.32 (95% confidence interval (CI): 0.19-0.56) for miscarriage and 0.40 (95%CI: 0.18-0.91) for premature birth. No significant difference was demonstrated in emerging GDM and PE.

CONCLUSIONS:

Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects.

KEYWORDS:

Metformin; miscarriage; polycystic ovary syndrome; pregnancy complications; premature birth

PMID:
26440203
DOI:
10.3109/09513590.2015.1041906
[Indexed for MEDLINE]

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