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Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14291-4. doi: 10.1002/anie.201505817. Epub 2015 Oct 6.

Stable Encapsulated Air Nanobubbles in Water.

Author information

1
Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, K7L 3N6 (Canada).
2
Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, K7L 3N6 (Canada). gliu@chem.queensu.ca.
3
Department of Biomedical and Molecular Sciences, Queen's University, 18 Stuart Street, Kingston, Ontario, K7L 3N6 (Canada).
4
Department of Medicine, Queen's University, Kingston General Hospital FAPC 3, 76 Stuart Street, Kingston, Ontario, K7L 2V7 (Canada).

Abstract

The dispersion into water of nanocapsules bearing a highly hydrophobic fluorinated internal lining yielded encapsulated air nanobubbles. These bubbles, like their micrometer-sized counterparts (microbubbles), effectively reflected ultrasound. More importantly, the nanobubbles survived under ultrasonication 100-times longer than a commercial microbubble sample that is currently in clinical use. We justify this unprecedented stability theoretically. These nanobubbles, owing to their small size and potential ability to permeate the capillary networks of tissues, may expand the applications of microbubbles in diagnostic ultrasonography and find new applications in ultrasound-regulated drug delivery.

KEYWORDS:

assembly; block copolymers; nanobubbles; nanocapsules; ultrasonography

PMID:
26439669
DOI:
10.1002/anie.201505817

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