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Muscle Nerve. 2016 May;53(5):705-10. doi: 10.1002/mus.24930. Epub 2016 Jan 27.

Endoneurial edema in sural nerve may indicate recent onset inflammatory neuropathy.

Author information

1
Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Abstract

INTRODUCTION:

Sural nerve biopsy is an important means of establishing the diagnosis of inflammatory neuropathies. We investigated the diagnostic value of endoneurial edema.

METHODS:

Diagnostic sural nerve biopsies from 42 patients with inflammatory and 28 patients with noninflammatory neuropathies were re-evaluated for the presence of endoneurial edema. Edema was assessed on hematoxylin-eosin stained paraffin and frozen sections and on azure II-methylene blue stained semithin sections. We determined the area of endoneurial edema on digitized images in relation to the entire endoneurial area of each fascicle.

RESULTS:

Edema was more extensive in neuropathies with short disease duration (≤12 months) as compared to long duration (>12 months; P < 0.01). Edema in inflammatory neuropathies of ≤12 months duration covered a larger area than in noninflammatory neuropathies (P < 0.01), and the extent of edema correlated negatively with disease duration (P < 0.05).

CONCLUSIONS:

Endoneurial edema may be a useful additional disease marker in inflammatory neuropathies of recent onset.

KEYWORDS:

diagnosis; endoneurial edema; histology; inflammatory neuropathy; noninflammatory neuropathy; polyneuropathy; sural nerve biopsy

PMID:
26439587
DOI:
10.1002/mus.24930
[Indexed for MEDLINE]

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