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Curr Biol. 2015 Oct 5;25(19):R820-2. doi: 10.1016/j.cub.2015.08.002.

Vectored antibody gene delivery mediates long-term contraception.

Author information

1
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
2
Beckman Institute Proteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.
3
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: haybruce@caltech.edu.

Abstract

Development of non-surgical methods of long-term or permanent contraception remains a challenge. Towards this objective, we show that intramuscular injection of a replication-incompetent, recombinant adeno-associated virus (rAAV) designed to express an antibody that binds gonadotropin-releasing hormone (GnRH), a master regulator of reproduction in vertebrates, results in long-term infertility in male and female mice. Female mice are also rendered infertile through rAAV-dependent expression of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surrounds the egg and functions as a sperm-binding site. Many proteins known or suspected to be important for reproduction can be targeted, potentially reversibly, using this approach, which we refer to as vectored contraception (VC).

PMID:
26439332
DOI:
10.1016/j.cub.2015.08.002
[Indexed for MEDLINE]
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