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Nat Rev Microbiol. 2015 Nov;13(11):663-76. doi: 10.1038/nrmicro3524. Epub 2015 Oct 6.

Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.

Author information

1
School of Medicine, University of California Riverside, Riverside, California 92521, USA.
2
The Division of Biology &Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
3
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Abstract

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

PMID:
26439085
PMCID:
PMC5201123
DOI:
10.1038/nrmicro3524
[Indexed for MEDLINE]
Free PMC Article

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