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Mol Neurodegener. 2015 Oct 5;10:52. doi: 10.1186/s13024-015-0048-1.

Genetics ignite focus on microglial inflammation in Alzheimer's disease.

Author information

1
Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. manasi.malik@uky.edu.
2
Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. ishita.parikh@uky.edu.
3
Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. jared.vasquez@uky.edu.
4
Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. conorsm@uic.edu.
5
Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. leontai@uic.edu.
6
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. bu.guojun@mayo.edu.
7
Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL, USA. mladu@uic.edu.
8
Department of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. david.fardo@uky.edu.
9
Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA. bill.rebeck@georgetown.edu.
10
Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA. steve.estus@uky.edu.

Abstract

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies.  We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.

PMID:
26438529
PMCID:
PMC4595327
DOI:
10.1186/s13024-015-0048-1
[Indexed for MEDLINE]
Free PMC Article

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