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Muscle Nerve. 2016 Jan;53(1):134-6. doi: 10.1002/mus.24929.

Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.

Author information

1
Neurology, Johns Hopkins Aramco Healthcare, Saudi Aramco, P.O. Box 2614, Dhahran, Saudi Arabia, 31311.
2
Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
3
Department of Physical Medicine and Rehabilitation, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
4
Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
5
Neurology, Kaiser Permanente Neurology, Panorama City, California, USA.

Abstract

INTRODUCTION:

Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function.

METHODS:

We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, and a respiratory therapist performed spirometry blinded to SBCT and strength results.

RESULTS:

Thirty-one patients, aged 57 ± 19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force, and neck flexor strength (P < 0.01). FVC showed significant correlation with neck flexor strength (P = 0.02) but no correlation with shoulder abductor strength.

CONCLUSIONS:

These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients.

KEYWORDS:

forced vital capacity; myasthenia gravis; neck flexor strength; negative inspiratory force; single breath count; spirometry

PMID:
26437790
PMCID:
PMC4715713
DOI:
10.1002/mus.24929
[Indexed for MEDLINE]
Free PMC Article

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