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Scand J Psychol. 2015 Dec;56(6):693-9. doi: 10.1111/sjop.12248. Epub 2015 Oct 6.

The relationship between the Five-Factor Model personality traits and peptic ulcer disease in a large population-based adult sample.

Author information

Department of Psychology, University of Tartu, Estonia.
Institute of Molecular and Cell Biology, University of Tartu, Estonia.
Estonian Genome Centre of University of Tartu, Estonia.
The Estonian Academy of Sciences, Estonia.


The current study examined the relationship between the Five-Factor Model personality traits and physician-confirmed peptic ulcer disease (PUD) diagnosis in a large population-based adult sample, controlling for the relevant behavioral and sociodemographic factors. Personality traits were assessed by participants themselves and by knowledgeable informants using the NEO Personality Inventory-3 (NEO PI-3). When controlling for age, sex, education, and cigarette smoking, only one of the five NEO PI-3 domain scales - higher Neuroticism - and two facet scales - lower A1: Trust and higher C1: Competence - made a small, yet significant contribution (p < 0.01) to predicting PUD in logistic regression analyses. In the light of these relatively modest associations, our findings imply that it is certain behavior (such as smoking) and sociodemographic variables (such as age, gender, and education) rather than personality traits that are associated with the diagnosis of PUD at a particular point in time. Further prospective studies with a longitudinal design and multiple assessments would be needed to fully understand if the FFM personality traits serve as risk factors for the development of PUD.


Five-Factor Model of personality; Neuroticism; Peptic ulcer disease

[Indexed for MEDLINE]

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