Format

Send to

Choose Destination
Trends Cell Biol. 2015 Nov;25(11):697-707. doi: 10.1016/j.tcb.2015.07.010. Epub 2015 Oct 1.

Ligand-Independent Mechanisms of Notch Activity.

Author information

1
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Current Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
2
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: wumin@bio.fsu.edu.

Abstract

Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur.

KEYWORDS:

Drosophila; Notch signaling; developmental biology; noncanonical cell signaling

PMID:
26437585
PMCID:
PMC4628868
DOI:
10.1016/j.tcb.2015.07.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center