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Mitochondrion. 2015 Nov;25:67-75. doi: 10.1016/j.mito.2015.10.001. Epub 2015 Oct 3.

Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies.

Author information

1
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona, 4, 70125, Bari, Italy.
2
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona, 4, 70125, Bari, Italy. Electronic address: angelamariaserena.lezza@uniba.it.

Abstract

Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA and interactions between TFAM and mtDNA participate to regulation of mitochondrial biogenesis. Such interactions are modulated through different mechanisms: regulation of TFAM expression and turnover, modulation of TFAM binding activity to mtDNA through post-translational modifications and differential affinity of TFAM, occurrence of TFAM sliding on mtDNA filaments and of cooperative binding among TFAM molecules, modulation of protein-protein interactions. The tissue-specific regulation of mitochondrial biogenesis in aging and calorie restriction (CR) highlights the relevance of modulation of TFAM-mtDNA interactions.

KEYWORDS:

Aging; Calorie restriction; Mitochondrial biogenesis; MtDNA; TFAM; TFAM–mtDNA interactions

PMID:
26437364
DOI:
10.1016/j.mito.2015.10.001
[Indexed for MEDLINE]

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